2016 Fiscal Year Final Research Report
The physiopathology and clinical significance of anti-MOG positive NMOSD
| Project/Area Number |
15K19472
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | antibody / MOG / demyelination / neuromyelitis optica |
|---|
| Outline of Final Research Achievements |
Neuromyelitis optica spectrum disorders (NMOSD) is characterised by optic neuritis and myelitis. Most of patients are positive for aquaporin-4 antibodies, but in a proportion of patients, there are seronegative patients with similar characteristics. We reported that some seronegative patients for aquaporin-4 antibodies are positive for anti-myelin oligodendrocyte glycoprotein (anti-MOG) antibodies. Further, anti-MOG positive cases are a group that differs from multiple sclerosis and aquaporin-4 antibody positive NMOSD.
|
| Free Research Field |
神経内科
|
