2016 Fiscal Year Final Research Report
Role of glycosaminoglycans in ATTR amyloidosis
| Project/Area Number |
15K19488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | グリコサミノグリカン / ヘパラン硫酸 / アミロイド / アミロイドーシス |
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| Outline of Final Research Achievements |
Transthyretin familial amyloid polyneuropathy (TTR-FAP) is characterized by transthyretin (TTR) deposition in various tissues, including the kidneys. Amyloid depositions in vivo contain protein components and non-protein constituents besides the main protein fibrils. The non-protein constituents include glycosaminoglycans (GAGs), and are thought to be involved in the pathogenesis and pathology of protein aggregation diseases, such as protein aggregation and protein aggregate-induced tissue/organ damages.Here, we showed that heparan sulfate and heparin, members of naturally occuring GAGs, promoted the aggregation of TTR and mediated the cellular interaction of TTR fibrils. Furthermore, heparan sulfate were accumulated in the kidneys of patients having TTR-FAP. Our results will assist in the design of anti-amyloid agents.
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| Free Research Field |
医化学一般
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