Investigating the pathophysiology of impairment of large-scale brain networks in the patients with epilepsy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19491
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: Uehara Taira 九州大学, 医学研究院, 助教 (30631585)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: てんかん

Outline of Final Research Achievements

We found rapid propagation of ictal fast activities including high-frequency oscillation (HFO) along well-known large-scale functional brain networks, such as default mode network (DMN), in the patients with intractable focal epilepsy. Interictal functional connectivity among DMN structures was not associated with the occurrence of ictal HFOs in DMN regions. The relation between hyperexcitability and functional connectivity of DMN in the patient with epilepsy was not clarified in this study.

Free Research Field

臨床神経生理学