Necessary environment for amelioration after ischemic reperfusion injury in brain: the role of L-serine

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19497
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Keio University
• Principal Investigator: Suzuki Masataka 慶應義塾大学, 医学部(信濃町), 特任助教 (90595000)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 虚血再灌流障害 / L-セリン

Outline of Final Research Achievements

In this study, I aimed to clarify how L-serine , which is suplied by astroglia, affects on neurogenesis after ischemic reperfusion injury in brain of MCAO mouse model. The size of infarct region after MCAO in Astroglia specific knock out of phosphoglycerate dehydrogenase (PHGDH) was not significantly different from that in flox/flox mice. L-serine activated phosphorylation of p70S6K in primary cortical neurons in vitro. Because p70S6K is the protein that facilitates protein synthesis and cell proliferation, L-serine possibly stimulates neurogenesis.

Free Research Field

神経科学