Elucidation of novel molecular mechanisms and therapeutic targets of hypertriglyceridemia

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19506
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: The University of Tokyo
• Principal Investigator: Takanashi Mikio 東京大学, 医学部附属病院, 特任助教 (70610799)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 脂質 / 糖尿病 / インスリン / ホルモン感受性リパーゼ / リポ蛋白リパーゼ

Outline of Final Research Achievements

The molecular mechanism of hypertriglyceridemia is not fully understood, so we do not have adequate therapeutic agents. In insulin deficient status, the plasma level of triglycerides is lower in hormone-sensitive lipase (HSL) deficient mice than in wild-type mice. The current study was aimed at elucidating the novel molecular mechanisms and therapeutic targets of hypertriglyceridemia. HSL-deficient mice and some other lipolytic gene deficient mice were used in this study. Under various statuses (insulin-deficient, treated with triton WR-1339, challenged with olive oil or medium chain triglycerides), we examined the plasma level of triglycerides and gene expressions. Novel molecular mechanism independent of lipoprotein lipase (LPL) was suggested, and which are currently under investigation.

Free Research Field

脂質異常症