2016 Fiscal Year Final Research Report
The role of a-ketoglutarate dehydrogenase on insulin secretion
| Project/Area Number |
15K19512
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Ogura Masahito 京都大学, 医学研究科, 特定助教 (00547812)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | αKGDHのインスリン分泌に及ぼす影響 |
|---|
| Outline of Final Research Achievements |
TCA cycle is important for insulin secretion from pancreatic β cells via ATP synthesis. a-ketoglutarate dehydrogenase is one of the enzyme in TCA cycle. Recently, there are some reports that indicate relationship between diabetes and dementia. It is also reported that the activity of a-ketoglutarate dehydrogenase is inhibited in the neuron in Alzheimer disease by oxidative stress.
We investigate the effect of a-ketoglutarate dehydrogenase on insulin secretion from pancreatic β cells using cell line or isolated islet from rodents. It was revealed that insulin secretion is affected by the inhibition of a-ketoglutarate dehydrogenase or depression of expression levels of a-ketoglutarate dehydrogenase.
|
| Free Research Field |
代謝学
|
