Investigation of the role of a novel regulator of insulin secretion

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19513
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kyoto University
• Principal Investigator: Nishi Kiyoto 京都大学, 医学研究科, 医員 (30749362)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: インスリン / 糖代謝 / エネルギー代謝 / 転写調節

Outline of Final Research Achievements

Type 2 diabetes (T2D) is characterized by impaired insulin secretion from pancreatic beta-cells and insulin resistance of the target tissues, such as liver, adipose tissue and muscles.
We analysed NRDC (N-arginine dibasic convertase; Nardilysin)-deficient mice and found that NRDC controls both insulin secretion and insulin sensitivity. Then, we generated organ-specific (pancreatic beta-cell, liver and adipose tissue) NRDC-deficient mice and found that (1) NRDC regulates pancreatic beta-cell function and identity, (2) NRDC regulates insulin sensitivity in both liver and adipose tissue. Part of these results was published in “Diabetes” journal.

Free Research Field

医歯薬学