Establishment of Anti-aging mechanism by NPY in the fat metabolism

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19517
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Nagasaki University
• Principal Investigator: PARK Seongjoon 長崎大学, 医歯薬学総合研究科(医学系), 助教 (60635853)
• Research Collaborator: KOMATSU Toshimitsu 長崎大学, 医歯薬学総合研究科(医学系), 技術職員
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: NPY / 食餌制限 / 脂肪代謝 / 老化

Outline of Final Research Achievements

We report that NPY-deficiency in male mice during CR increases mortality in association with lipodystrophy. NPY-/- mice displayed a rapid decrease in body weight and fat mass, as well as increased lipolysis during CR. These alterations in fat regulation were inhibited by the lipolysis inhibitor, acipimox (ACM), a treatment associated with reduced mortality. The lipolytic/thermogenic signaling, β3-adrenergic receptor/hormone sensitive lipase was markedly activated in white adipose tissue of NPY-/- mice compared with that of NPY+/+ mice, and thermogenesis was controlled by NPY under negative energy balance. These results demonstrate the critical role of NPY in the regulation of lipid metabolic homeostasis and survival via control of lipolysis and thermogenesis in a state of negative energy balance.

Free Research Field

老化学