2016 Fiscal Year Final Research Report
The role of ILDR2 in ER stress and hepatic steatosis
| Project/Area Number |
15K19523
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Research Collaborator |
Leibel Rudolph Columbia University, Department of Pediatrics, Professor
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 脂肪肝 / ERストレス |
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| Outline of Final Research Achievements |
A diabetes susceptibility gene, immunoglobulin-like domain containing receptor 2 (Ildr2), encodes a transmembrane protein localized to the endoplasmic reticulum membrane that is closely related to hepatic lipid metabolism. The livers of ob/ob mice in which Ildr2 is transiently overexpressed are relieved of hepatic steatosis. However, the molecular mechanisms through which ILDR2 affects these changes in hepatic lipid metabolism remain unknown.
We purified ILDR2-containing protein complexes using tandem affinity purification tagging and identified several ILDR2 binding proteins. This result supports a novel link between ILDR2 and ILDR2-interacting proteins and suggest that ILDR2 is involved in a novel pathway in hepatic steatosis.
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| Free Research Field |
分子生物学
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