2016 Fiscal Year Final Research Report
Influence of metabolic syndrome-associated gene KAT-1 on glucose metabolism
| Project/Area Number |
15K19524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | メタボリックシンドローム / キヌレン酸 |
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| Outline of Final Research Achievements |
It is well known that metabolic syndrome is associated with lifestyle and genetic factor but precise mechanism of pathogenesis of metabolic syndrome is unclear. Present study found that in metabolic syndrome-associated gene KAT1 knockout mice kynurenic acid contents in some tissues was decreased and glucose intolerance and insulin-resistant state were observed. Furthermore, increasing endogenous kynurenic acid contents ameliorated glucose intolerance in diabetic mice with diet-induced obesity. The therapeutic intervention to manipulate metabolism of kynurenic acid may be an effective tool for controlling progression of diabetes mellitus and metabolic syndrome.
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| Free Research Field |
生化学
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