2016 Fiscal Year Final Research Report
Antigen specific therapy for rheumatoid arthritis
Project/Area Number |
15K19565
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Collagenous pathology/Allergology
|
Research Institution | University of Tsukuba |
Principal Investigator |
HIROTA Tomoya 筑波大学, 附属病院, 病院講師 (30742845)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | 関節リウマチ / Altered Peptide Ligand / GPI |
Outline of Final Research Achievements |
To investigate the effects of transgenic rice seeds expressing the altered peptide ligand (APL) of human glucose-6-phosphate-isomerase (GPI) in mice model of GPI-induced arthritis (GIA). Prophylactic treatment of GIA mice with APL12 transgenic (APL12-TG) rice seeds significantly reduced the severity of arthritis and titers of serum anti-GPI antibodies. APL12-TG rice seeds improved the histopathological arthritis scores and decreased IL-17 production. APL12-TG rice-treated GIA mice showed upregulation of Foxp3 and GITR protein in CD4+CD25+Foxp3+ cells in the spleen. APL12-TG rice seeds improved the severity of GIA through a decrease in production of IL-17 and anti-GPI antibodies via upregulation of Foxp3 and GITR expression on Treg cells in spleen.
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Free Research Field |
臨床免疫学
|