Investigation on the effect of previous sensitization on tolerance induction by oral antigen administrarion

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: The University of Tokyo
• Principal Investigator: HARADA Hiroaki 東京大学, 医学部附属病院, 助教 (40579687)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: アレルギー学

Outline of Final Research Achievements

Although oral administration of ovalbumin to naive mice leads tolerance to the antigen, the same procedure to previously sensitized mice fails tolerance induction. Orally administered ovalbumin is absorbed in the intestine and carried to mesenteric lymph nodes, where T cells who recognize the antigen are prone to differentiate into regulatory T cells. However, in sensitized mice, regulatory T cell differentiation is inhibited, and it is attributed to antigen presenting cells rather than sensitized T cells.

Free Research Field

医歯薬学