Optimization of the treatment of systemic lupus erythematosus by immunological classifications

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19579
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: Keio University
• Principal Investigator: Kikuchi Jun 慶應義塾大学, 医学部(信濃町), 助教 (20570881)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 全身性エリテマトーデス

Outline of Final Research Achievements

The aim of this study was to analyze the pathogenesis of SLE leading to optimization of the management. We selected the molecule, Milk Fat Globule Epidermal growth factor 8 (MFG-E8), with comprehensive protein analysis. We reported that MFG-E8 positive peripheral monocytes correlated with the disease activity, and were higher in patients with skin, musculoskeletal and lymphocytopenia. In addition, the subpopulations of peripheral CD8 positive T cells correlated with disease activity and were associated with some clinical organ characteristics. Our study indicated the possibility that immunological approach with serum proteins and peripheral immune cells may enable us to classify and implement personalized management.

Free Research Field

リウマチ・膠原病