2017 Fiscal Year Final Research Report
Analysis of platelet involvement in IL-33-dependent airway inflammation
| Project/Area Number |
15K19581
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kansai University of Health Sciences |
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Principal Investigator |
Takeda Tomohiro 関西医療大学, 保健医療学部, 准教授 (20717665)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | IL-33 / 血小板 |
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| Outline of Final Research Achievements |
Platelets are known to be involved in the pathogenesis of allergic diseases, but the mechanism is unknown. In this study, we found that full-length IL-33 is expressed in platelets. In addition, platelet-derived IL-33 was confirmed to have biological activity by examination using the mouse asthma model, deeply involved in Type 2 inflammation, and to be involved in the pathogenesis of allergic airway inflammation .
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| Free Research Field |
免疫
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