Effects of Aerobic vs. Anaerobic Culture on In-Vivo and In-Vivo Virulence of Streptococcus pneumoniae

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19583
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Hokkaido University
• Principal Investigator: Nagaoka Kentaro 北海道大学, 大学病院, 医員 (20750962)
• Research Collaborator: KONNO SATOSHI 北海道大学, 北海道大学病院, 准教授 (20399835) ; NISHIMURA MASAHARU 北海道大学, 北海道大学病院, 教授 (00208224)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 肺炎球菌 / 肺炎 / ニューモリシン / 嫌気性菌

Outline of Final Research Achievements

In this study, we examined whether the culture condition of either aerobic or anaerobic might be influential to the virulence of Streptococcus pneumoniae, which is a facultative anaerobic bacterium. We here demonstrate that the virulence of S. pneumoniae is highly enhanced in vivo when pre-cultured under anaerobic condition compared with aerobic condition. This is the first report, which validated the difference of pathogenicity between aerobic and anaerobic condition. We consider that the results of our study is important for investigating the pathogenesis of facultative bacterium.

Free Research Field

呼吸器感染症