Helicobacter pylori gastritis and1 gastric mucosal immunity in patients with HIV

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19584
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Eisuke Adachi 東京大学, 医科学研究所, 助教 (80725804)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ヘリコバクター・ピロリ / HIV感染症 / 腸管遊走性リンパ球 / マイクロビオーム

Outline of Final Research Achievements

The aim of this research is to assess the contribution of gastric mucosal immunity and Helicobcter pyloi in people living with HIV (PLWH). We conducted a prospective study of PLWH who underwent upper gastrointestinal endoscopy. Peripheral blood mononuclear cells were collected at the same point to determine the frequency of peripheral blood gut homing CD4+ T cells and CD4+ memory T cells subsets by flow cytometry and Biopsy specimens was obtained to investigate gastric micobiome. The result of this research showed the association of Gut homing CD4+ T cells with chronic active gastritis and indirect colonization resistance by host mucosal immunity may affect the gastric microbiome In PLWH with CD4>200.

Free Research Field

感染症内科