2016 Fiscal Year Final Research Report
The survival strategies of pathogenic mycobacteria in host phagocytes through ManLAM binding to glycosphingolipid
| Project/Area Number |
15K19592
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Infectious disease medicine
|
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | リポアラビノマンナン（LAM） / ラクトシルセラミド（LacCer) / 結核菌 / 抗酸菌 / ヒト好中球 / 食胞成熟 / ManLAM / Hck |
|---|
| Outline of Final Research Achievements |
Mycobacterium tuberculosis inhibit the fusion of lysosome with phagosome. Here, we studied how lactosylceramide (LacCer) recognizes mycobacterial lipoarabinomannan (LAM). We showed that LacCer binds to α1,2-mannose side branches of LAM, which are common structures among mycobacterial species. Furthermore, our data suggest ManLAM inhibits the large cluster formation of LacCer on phagosomes, resulting in the abrogation of LacCer/Hck interaction. These results provide new insights into how pathogenic mycobacteria parasite in host phagocytes.
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| Free Research Field |
生化学、糖鎖生物学、感染免疫学
|
