2016 Fiscal Year Final Research Report
The effect of microbiota on the gut barrier maturation
| Project/Area Number |
15K19607
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OH-OKA Kyoko 山梨大学, 総合研究部, 医学研究員 (50569019)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 小児免疫 / 腸管バリア機能 |
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| Outline of Final Research Achievements |
The purpose of this study is to show whether the gut barrier maturation of infants is affected by microbiota of mother. The expression level of several tight junction proteins, which regulate intestinal barrier function, was increased depending on the week-old. Next, I analyzed whether the gut barrier maturation of infants is changed or not, after changing the microbiota of mother by administration of pro-biotics and polyphenol. It is suggested that a particular lactobacillus and resveratrol affect to the gut barrier function.
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| Free Research Field |
免疫学
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