2017 Fiscal Year Final Research Report
A novel therapy using mesenchymal stem cells for brain injury caused by status epilepticus
| Project/Area Number |
15K19614
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IWATANI Sota 神戸大学, 医学部附属病院, 助教 (00741430)
YAMANA Keiji 神戸大学, 医学部附属病院, 助教 (80792936)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | mesenchymal stem cell / umbilical cord / lung injury / inflammation / status epilepticus |
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| Outline of Final Research Achievements |
Status epilepticus is a major neurological emergency that is associated with significant morbidity and mortality. A number of treatment strategies have been attempted to improve outcomes of status epilepticus, however, there is no solid evidence for the efficacy of treatments. Mesenchymal stem cells (MSCs) have been shown to have neuroprotective effects in adult animal models of many conditions such as hypoxic ischemic encephalopathy. In this research, we have clarified that the MSCs derived from human umbilical cord of preterm babies had high proliferative ability associated with WNT signaling pathways compared with those of term babies. Further, we have suggested that the lung damages and inflammation on rat model of bleomycin-induced injury was rescued by MSCs derived from human umbilical cord.
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| Free Research Field |
小児科学
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