Fecal Microbiota Transplantation for pediatric ulcerative colitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19647
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: National Center for Child Health and Development
• Principal Investigator: SHIMIZU HIROTAKA 国立研究開発法人国立成育医療研究センター, 器官病態系内科部, 医師 (80751198)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: FMT / ulcerative colitis / children

Outline of Final Research Achievements

We performed FMT to 9 children with ulcerative colitis until the end of March 2018. Favorable results were achieved in relatively mild patients. However, most part of the candidates for this study were already resistant to several drugs including biologics and / or steroid and intended to avoid colectomy. In these patients, the result of FMT was not promising.
We reported a case successfully treated with repeated FMTs on Pediatric International. We presented 5 cases treated with repeated FMTs at WCPGHAN held in Canada. At AIBD 2017 in USA, we reported the impact on microbiota by blending the FMT solutions under aerobic condition.

Free Research Field

Gastroenterology