The ratio of urinary coproporphyrin in pediatric period

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19655
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: Kondo Sonoko 香川大学, 医学部, 助教 (70437680)
• Research Collaborator: OKADA Hitoshi 香川大学, 医学部, 准教授 (30253272) ; IWASE Takashi 香川大学, 医学部附属病院, 講師 (30284368) ; KATO Ikuko 香川大学, 医学部, 助教 (00613720) ; SUGINO Masashiro 香川大学, 医学部附属病院, 病院助教 (50793220)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: UCP比 / 正期産児 / 早産児 / MRP2

Outline of Final Research Achievements

The ratio of urinary coproporphyrinⅠto total urinary coproporphyrinⅠand Ⅲ(UCP［Ⅰ/(Ⅰ+Ⅲ)］) was analyzed by age group. The mean UCP［Ⅰ/(Ⅰ+Ⅲ)］was 0.47 at 0-6 months, 0.21 at 6 months to 1year, 0.17 at 1year, 0.13 at 2 years, 0.21 at 3 years and 0.27 at >4 years of age. In the infants<6months old, no significant correlation was noted between postnatal age and UCP［Ⅰ/(Ⅰ+Ⅲ)］, whereas a significant inverse correlation was noted between corrected gestational age and UCP［Ⅰ/(Ⅰ+Ⅲ)］. Also, significant inverse correlation was observed between postnatal age and UCP［Ⅰ/(Ⅰ+Ⅲ)］in term infant group, while no significant inverse correlation was observed in preterm infant group.
Furthermore, while no significant inverse correlation was seen in preterm infants group, significant inverse correlation was seen between corrected gestational age and UCP［Ⅰ/(Ⅰ+Ⅲ)］in term infant group.

Free Research Field

胎児・新生児学