2017 Fiscal Year Final Research Report
Effect of valproic acid on murine embryonic heart and explication of molecular biology mechanism
| Project/Area Number |
15K19659
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Kanai Yuji 福島県立医科大学, 医学部, 助手 (60448628)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バルプロ酸ナトリウム / 胎児催奇形性 / 心血行動態 / 先天性心疾患 / ヒストン脱アセチル化酵素 |
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| Outline of Final Research Achievements |
We evaluated the effect of valproic acid on developing murine embryonic heart function using high-resolution echocardiography in utero. By making an embryo model by VPA administration to the pregnant murine, we assessed the fetal bradycardia and reduction of carotid artery flow volume.
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| Free Research Field |
小児科学
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