Morphological and functional change of placenta and predictive biomarker for heart failure in fetus with congenital heart disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19666
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Miyoshi Takekazu 国立研究開発法人国立循環器病研究センター, 病院, 医師 (70626697)
• Research Collaborator: MINAMINO NAOTO 国立循環器病研究センター, 創薬オミックスセンター, センター長 ; HOSODA HIROSHI 国立循環器病研究センター, 再生医療部, 室長 ; MIYAZATO MIKIYA 国立循環器病研究センター, 生化学部, 部長 ; SHIRAISHI ISAO 国立循環器病研究センター, 教育推進部, 部長 ; KUROSAKI KENICHI 国立循環器病研究センター, 小児循環器部, 部長 ; UEDA HATSUE 国立循環器病研究センター, 病理部, 部長 ; MATSUYAMA TAKAAKI 国立循環器病研究センター, 病理部, 医師 ; YOSHIMATSU JUN 国立循環器病研究センター, 周産期・婦人科部, 部長 ; KANGAWA KENJI 国立循環器病研究センター, 研究所長
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 胎児心不全 / 心疾患 / 不整脈 / 胎児治療 / 出生前診断 / 超音波検査 / ナトリウム利尿ペプチド / バイオマーカー

Outline of Final Research Achievements

In this study, the pathological changes of fetus, placenta and mother for fetal heart failure in fetus with congenital heart disease were cross-sectionally analyzed. Plasma natriuretic peptide levels in fetuses with congenital heart defects, arrhythmias, or both were correlated with the severity of fetal heart failure. In amniotic fluid, NT-pro BNP levels in fetuses with congenital heart defects, arrhythmias, or both were correlated with the severity of fetal heart failure, suggesting the possibility of clinical application as a biomarker. According to the severity of fetal heart failure, specific changes were found in the placental villi such as dysplasia, edematous degeneration and fibrosis, suggesting the degenerative and compensatory response secondary to fetal-placental hemodynamic change. Soluble FASL and TGF-α were identified as candidate molecules as maternal blood biomarkers for fetal heart failure.

Free Research Field

胎児心不全