2016 Fiscal Year Final Research Report
The role of ICOS signal in dermatitis using humanized mice
| Project/Area Number |
15K19682
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
OGAWA Youichi 山梨大学, 総合研究部, 助教 (20377542)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 共刺激分子 / 皮膚炎 / 接触性皮膚炎 / アトピー性皮膚炎 / 乾癬 / ヒト化マウス |
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| Outline of Final Research Achievements |
Proper T cell activation requires at least two signals. SIgnal1: binding of MHC complex on APC and T cell receptor on T cells. Signal2: Co-stimuratory signals via APC to T cells. Lack of co-stimuratory signals results in inadequate T cell activation, leading to anergy of T cells. It is not clear how ICOS signal, one of the co-stimuratory signals, is involved in the development and exacerbation of dermatitis. We investigated the role of ICOS signal in Th1-, Th2-, Th17-type dermatitis.
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| Free Research Field |
皮膚免疫、ウイルス感染症、膠原病
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