Analysis on the influence of the HDAC inhibitor in the keloid formation

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19693
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Nagasaki University
• Principal Investigator: KUWATSUKA Yutaka 長崎大学, 医歯薬学総合研究科(医学系), 助教 (90437864)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ケロイド / HDAC阻害剤 / エピジェネティクス

Outline of Final Research Achievements

We examined the gene expressions of extracellular matrix and transcription factors in keloid cells with HDAC inhibitor in vitro. Previously, we found HDAC2 was upregulated in the keloid tisuue, therefore, we choose Mocetinostat and Apicidin in addition to SAHA as HDAC inhibitors. As a result, any HDAC inhibitors could inhibit the COL1A2 mRNA expressions, especially apicidin could inhibit COL1A2 greater extent. Moreover, lower gene expressions were detected in the apicidin. These suggests apicidin improve the hypoxic stress and fibrosis in the keloid. More number of the studies and further mechanism examination would be needed.

Free Research Field

皮膚科学