Elevation of SC pH accelarate epidermal innervation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19696
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Oita University
• Principal Investigator: Akiko Ito 大分大学, 医学部, 客員研究員 (70457620)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 角層pH / 表皮内神経伸長 / アトピー性皮膚炎

Outline of Final Research Achievements

Elevation of stratum corneum (SC) pH influenced the expressions of nerve growth factor and semaphorin 3 in epidermis and augmented the epidermal innervation. In addition, elevation of SC pH induced scratching of flaky tail mice having filaggrin mutation with augmentation of epidermal innervation. These results suggest that elevation of SC pH is involved not only in induction of itching but also in the collaboration of environmental factors and genetic ones in the pathogenesis of atopic dermatitis.
In signal transducer and activator of transcription-6 (STAT6) mice, SC pH was downregulated with elevation of filaggrin expressions in epidermis and decrease in number of mast cells in dermis. These results suggest that epidermal innervation might be regulated by collaboration of SC pH, Th2 cytokines, mast cells, and epidermal keratinocytes.

Free Research Field

皮膚科学