2017 Fiscal Year Final Research Report
The study of relationship between stress response and pathogenesis of Hailey Hailey disease using cell culture model
| Project/Area Number |
15K19707
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ヘイリーヘイリー病 / 疾患モデル / 三次元培養 / RNAi / 小胞体ストレス / ゴルジ体ストレス |
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| Outline of Final Research Achievements |
The precise mechanism of development of skin lesions in Hailey-Hailey disease (HHD) remains unclear, mainly because of difficulty in obtaining skin samples due to the rarity of HHD and lack of an animal model. In this study, we generated 3D culture models using primary keratinocytes derived from an HHD patient and keratinocytes in which ATP2C1 mRNA was down-regulated with the RNAi method. Furthermore, we showed that endoplasmic reticulum and golgi stress may contribute to the pathogenesis of this disease.
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| Free Research Field |
皮膚科学
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