The cross-frequency coupling of neural oscillations in schizophrenia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19713
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: KIRIHARA Kenji 東京大学, 医学部附属病院, 助教 (80553700)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 統合失調症 / 脳波 / ミスマッチ陰性電位 / 神経オシレーション / グルタミン酸

Outline of Final Research Achievements

We investigated mismatch negativity and neural oscillations in early stages of schizophrenia. In this study, we found that mismatch negativity showed no progressive reduction, association with social functioning and cognitive functioning, and association with plasma level of glutamate in early stages of psychosis. In addition, we also found altered cross-frequency coupling of neural oscillations in early stages of psychosis. These findings suggest that mismatch negativity and the cross-frequency coupling may be useful biomarkers for early stages of schizophrenia.

Free Research Field

精神医学