2016 Fiscal Year Final Research Report
Investigation of primary cilia pathology in schizophrenia
| Project/Area Number |
15K19714
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Hiroki Shiwaku 東京医科歯科大学, 医学部附属病院, 医員 (90747502)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 統合失調症 / primary cilia / NMDA受容体 / 精神疾患 |
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| Outline of Final Research Achievements |
We investigated the effects of psychotomimetics, phencyclidine, MK-801 (dizocilpine), and methamphetamine, on morphological and molecular indices in the rodent brain. The brain region-selective modulation of primary cilia was observed by gene expression analysis and immunohistochemical analysis. These findings were linked to NMDAR hypofunction. NMDAR hypofunction-induced dysregulation of primary cilia could be involved in the pathophysiology of schizophrenia.
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| Free Research Field |
精神神経薬理学
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