Development of new biomarker for diagnosis and pharmacological treatment response prediction of ADHD

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19719
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Shinshu University
• Principal Investigator: SASAYAMA Daimei 信州大学, 学術研究院医学系, 准教授 (90447764)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 注意欠如・多動症 / サイトカイン / コルチゾール / 唾液

Outline of Final Research Achievements

The present study aimed to develop a new biomarker for diagnosing and understanding the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). Children with and without ADHD were administered psychological tests, symptom rating scales, and IVA-CPT. Salivary cytokine and cortisol levels were measured. Our results showed that many of the salivary cytokines in children exhibit diurnal variation. Furthermore, we showed that response control and attention were significantly negatively correlated with awakening cortisol levels.

Free Research Field

精神医学