Elucidation of neural mechanisms in antidepressant and cognitive behavioral therapy for chronic pain

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19730
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: Yoshino Atsuo 広島大学, 医歯薬保健学研究科(医), 特任助教 (90633727)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 慢性疼痛 / 認知行動療法 / fMRI

Outline of Final Research Achievements

We conducted cognitive behavioral therapy (CBT) or antidepressant treatment for chronic pain, and examined pain ratings, psychological ratings, and a neuroimaging method (fMRI) at pretreatment and post-treatment. Our outcomes were as follows: 1) the neural changes of the orbitofrontal cortex, inferior parietal lobule, and paracentral lobule by CBT (Yoshino et al., 2018) and 2) the different resting-state neural activities of the dorsolateral prefrontal cortex and thalamus from depressive patients and healthy controls (Yoshino et al., 2017). We clarified a pathological mechanism of chronic pain and a neural change by treatment.

Free Research Field

精神医学