2016 Fiscal Year Final Research Report
Investigation of the molecular basis for social experience-depencent neural development in prefrotal cortex
Project/Area Number |
15K19742
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Nara Medical University |
Principal Investigator |
KIMOTO SOHEI 奈良県立医科大学, 医学部, 助教 (00405391)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 社会経験 / 前頭前野 / 神経活動依存性 |
Outline of Final Research Achievements |
Social experience during early childhood has been suggested to play crucial roles in brain development and neuronal activity, especially for mental function. To clarify the molecuar basis underlying social experience-dependent neural plasticity, we compared gene expression in medial prefronal cortex between isolate-housing mouse (be housed in isolation from postnatal 21 day to 35 day) and group-housing mouse. We found that the expression of activity-regulated genes that are critical regulators for excitatory and inhibitory balance, and inflammatory-related genes were temporally altered in isolate-housing mouse compared to group-housing mouse. The present data suggest that these molecular changes might contribute to prefrontal dysfunction triggered by social isolation.
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Free Research Field |
分子精神医学
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