2017 Fiscal Year Final Research Report
Widespread white matter microstructural abnormalities related to cognitive impairment in bipolar disorder and major depressive disorder: A DTI study
| Project/Area Number |
15K19744
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 気分障害 / 白質微細構造異常 / 認知機能障害 / DTI |
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| Outline of Final Research Achievements |
The FA of WM in widespread regions including CC in the BD, and MDD groups was significantly reduced compared with those in the HC group. The mean FA of the WM skeleton with statistical differences correlated with performance on the list learning in the BD group, and correlated with performance on the digit sequencing task, token motor, and symbol coding in the MDD group. Our results suggested widespread WM microstructural abnormalities, which were associated with cognitive impairment in patients with BD and MDD. This study contributes to the understanding of WM pathophysiology in BD and MDD.
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| Free Research Field |
気分障害を対象にDTI を手法とした脳画像研究
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