2017 Fiscal Year Final Research Report
A study of the effect of EP receptor inhibitors on Alzheimer's disease
| Project/Area Number |
15K19752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ミクログリア |
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| Outline of Final Research Achievements |
Prostaglandin E2 (PGE2) potentiated interferon-γ (IFN-γ)-induced nitric oxide production in cultured rat microglia. Instead of PGE2, EP2 agonist, butaprost, enhanced IFN-γ-induced nitric oxide production, and EP2 antagonist, TG4-155, reversed the effect of PGE2 on IFN-γ-induced nitric oxide production. These results suggest that PGE2 activates EP2 receptor, which potentiates IFN-γ-induced nitric oxide production. PGE2 is also reported to reduce phagocytosis of amyloid-β in microglia, indicating that Alzheimer's disease is exacerbated by PGE2 signaling. It is, therefore, suggested that the inhibition of PGE2 signaling is a potential strategy for the treatment of Alzheimer's disease.
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| Free Research Field |
神経科学
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