Combination with carbon ion radiotherapy and chemotherapy or non small cell lung cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19770
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: Kubo Nobuteru 群馬大学, 医学部附属病院, 助教 (30727813)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 重粒子 / 炭素イオン線 / 非小細胞肺癌 / 化学放射線療法

Outline of Final Research Achievements

Using the non-small cell lung cancer cell lines, the sensitizing effect of carbon ion beam and anticancer agent was investigated. As a result of in vitro experiments, it was confirmed that sensitizing effect was almost equal or a little lower than that of X rays. This suggested the combination with carbon ion radiotherapy and anticancer drugs (carboplatin and paclitaxel) for non-small cell lung cancer are useful. As a clinical approach, we studied the difference in dose distribution between X-rays and carbon ion beams for locally advanced lung cancer. Compared with X-ray, carbon ion radiotherapy provides a more homogeneous target dose and a lower dose to organs at risk than X-ray radiotherapy for Stage IIIA non-small cell lung cancer.

Free Research Field

腫瘍放射線