2016 Fiscal Year Final Research Report
Anti cancer specific immune response after carbon ion irradiation
Project/Area Number |
15K19771
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Gunma University |
Principal Investigator |
Sato Hiro 群馬大学, 医学部附属病院, 医員 (90750571)
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Keywords | 放射線腫瘍学 / 腫瘍免疫学 |
Outline of Final Research Achievements |
I found that carbon ion radiotherapy induced high-mobility group box 1 (HMGB1) release, and T cell activation and proliferation in mice with lymphoma. HMGB1 is a member of damage-associated molecular pattern, which is released by irradiated tumor cells and trigger the activation of antigen presentation cells (APCs). APCs present the tumor-derived antigens to cytotoxic T lymphocytes, which then kill the target cells. Therefore, the present data suggested that tumor cell death by carbon ion radiotherapy elicited activation of tumor antigen specific immune response.
|
Free Research Field |
放射線生物学
|