Optimization of Crohn disease activity assessment by using MR enterocolonography

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K19778
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KITAZUME Yoshio 東京医科歯科大学, 医学部附属病院, 講師 (00625478)
• Research Collaborator: FUJIOKA Tomoyuki ; OYAMA Jun ; FUJII Toshimitsu ; TAKENAKA Kento ; OHTSUKA Kazuo ; TAKEISHI Ukihide
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 磁気共鳴画像 / クローン病 / 活動性評価

Outline of Final Research Achievements

A main achievement of this research task is as follows: a five-point magnetic resonance (MR) enterocolonography classification score for assessment of Crohn disease activity has been originally developed by using visual assessment alone, and the efficacy of the MR enterocolonography classification has been proven. Additional achievements were as follows: various MR imaging and assessments such as MR diffusion-weighted imaging, gadolinium contrast-enhancement, and cine MR imaging acquired with repeats of a rapid MR sequence, were shown to be feasible or useful for improving diagnostic accuracy in Crohn disease, by using balloon-assisted enteroscopy as a reference standard.

Free Research Field

放射線診断

Academic Significance and Societal Importance of the Research Achievements

クローン病活動性評価のためのMRスコアとして知られ、多くの文献で用いられているMagnetic Resonance Index of Activity (MaRIA)は、視覚的評価と計測結果から算出する必要があるため煩雑な作業が必要であり、代替となる簡便な評価法の確立は喫緊の課題であった。本研究から考案された5-point MR scoreは視覚的に5段階に分類する方法であり、短時間で評価できるため、日常診療だけでなく治療効果の判定などの臨床研究への応用が期待できる。