2017 Fiscal Year Final Research Report
Quantitative measurement of optical parameters by time-resolved near-infrared spectroscopy in breast cancer
| Project/Area Number |
15K19781
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 近赤外光 / 乳癌 |
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| Outline of Final Research Achievements |
Hemoglobin concentration and tissue oxygen saturation (SO2) of breast cancer can be measured noninvasively by near-infrared time-resolved spectroscopy system (TRS). The purpose of this study was to evaluate the effects of the thickness and depth of tumors on hemoglobin measurements in breast cancer by TRS, and to demonstrate SO2 and reduced scattering coefficient (μs’) in breast tissue and breast cancer in relation to the skin-to-chest wall distance. There was a positive correlation between total hemoglobin concentration (tHb) and tumor thickness, and a negative correlation between tHb and tumor depth. SO2 in breast tissue decreased when the skin-to-chest wall distance decreased, and SO2 in tumors tended to be lower than in breast tissue. In breast tissue, there was a negative correlation between μs’ and the skin-to-chest wall distance, and μs’ in tumors was higher than in breast tissue.
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| Free Research Field |
放射線診断学
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