2017 Fiscal Year Final Research Report
PET imaging of astrocytes during the development of Alzheimer's disease
| Project/Area Number |
15K19787
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | アストロサイト / PET |
|---|
| Outline of Final Research Achievements |
Fluorocitrate (FC) is a metabolic inhibitor of tricarbonic acid (TCA) cycle specifically in astrocyte and acetate uptake is a marker of astrocytic TCA cycle activity in brain. Oxygen-15 (15O) PET is the reference standard for quantitative assessment of cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2). The primary purpose of this study was to evaluate whether the inhibition of astrocytic TCA cycle metabolism by FC will affect the oxygen metabolism in the rat brain. There were no significant differences between the ipsilateral and contralateral striatum in each parameter using the 15O-gas PET. In 14C-acetate autoradiography results, there is significant inhibition in the astrocyte metabolism after FC injection in the ipsilateral striatum.Regional cerebral oxygen consumption as well as hemodynamic parameters was maintained against the inhibition of astrocytic TCA cycle metabolism in the rat brain.
|
| Free Research Field |
PET分子イメージング
|
