2017 Fiscal Year Final Research Report
Salivary gland regeneration after radiation damage by using adipose tissue derived stem cell
| Project/Area Number |
15K19790
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 放射線治療 / 唾液腺障害 / 脂肪組織由来幹細胞 |
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| Outline of Final Research Achievements |
The primary objective was to recover radiation salivary gland injury using adipose tissue-derived mesenchymal stem cells (ADSC). First, we prepared radiation-induced salivary gland disorder model mice, and confirmed that salivary secretion was reduced due to irradiation dose. Administration of ADSC to the salivary glands after irradiation did not improve salivary secretion reduction, but contrary to the initial expectation. However, we unexpectedly found the possibility of neuropathy as a cause of salivary gland injury. We would like to study the improvement of salivary gland function from the viewpoint of neuropathy.
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| Free Research Field |
放射線科学
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