Development of a new treatment method using Platelet-Rich Plasma for radiation adverse events

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19793
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Matsuo Yoshiro 神戸大学, 医学部附属病院, 医員 (90749201)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 放射線脱毛 / 多血小板血漿

Outline of Final Research Achievements

To radiation induced hair loss model rats, Platelet-Rich Plasma (PRP) was administered while changing radiation dose, administration method, and administration timing. A confirmation experiment was performed with the combination which seemed to be the most effective, and after macroscopic examination until 7 weeks after the irradiation, tissue collection and examination using a stained tissue were performed.
In the macroscopic evaluation, the degree of radiation-induced hair loss was reduced in the group injected with PRP intradermally for the group not given any dose to the irradiation and the group injected with the saline intradermally. In the histological examination using tissues collected 7 weeks after irradiation, the number of hair follicles was higher in the group injected intradermally with PRP than in other groups. PRP has been shown to be effective against radiation-induced hair loss.

Free Research Field

放射線腫瘍学