2018 Fiscal Year Final Research Report
Development of new methods to predict occurrence of radiation pneumonitis
| Project/Area Number |
15K19798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 放射線肺臓炎 / 呼気凝縮液 |
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| Outline of Final Research Achievements |
I performed a prospective clinical study entitled ‘Exhaled breath condensate (EBC) collection in normal healthy volunteers’. An adequate amount of EBC was collected from all subjects. Changes in vital signs were little among the collection in all subjects. Therefore, EBC collection in my procedures seems to be feasible and safe.
Then, a prospective observational study entitled ‘Relationship between radiation pneumonitis and TGF-β1 concentration in EBC’ is under way. In an interim analysis, it seems that (1) EBC collection in my procedures may be feasible and safe in patients with lung cancer, (2) total protein and TGF-β1 concentration in EBC may increase by radiation therapy, and (3) a high value of TGF-β1 concentration in EBC may relate to occurrence of Grade 2 radiation pneumonitis.
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| Free Research Field |
放射線科学
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| Academic Significance and Societal Importance of the Research Achievements |
直接的に肺や気道のTGF-β1を測定できる検体として気管支肺胞洗浄液があるが、放射線肺臓炎に関連する臨床研究の近年の報告はなく、採取の侵襲性の高さが一因ではないかと推察される。一方、しんどい思いをせずに気道の炎症物質を測定できる検体として呼気凝縮液があるが、放射線肺臓炎に関連する研究で呼気凝縮液が用いられた報告はない。今回はじめて、放射線治療によって呼気凝縮液内の総タンパク質濃度やTGF-β1濃度が上昇する可能性、呼気凝縮液内のTGF-β1濃度高値とGrade 2の放射線肺臓炎が関連している可能性が示唆されたため、本研究の成果は新たな知見として意義があると考える。
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