Low-Dose Gamma Knife Radiosurgery Plus Whole-Brain Radiation Therapy for Advanced Stage Brain Metastasis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K19805
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: Miyakawa Akifumi 名古屋市立大学, 大学院医学研究科, 研究員 (60624012)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 転移性脳腫瘍 / ガンマナイフ治療 / 全脳照射

Outline of Final Research Achievements

From November 2013 to March 2016, 42 patients were treated with Gamma Knife (GK) followed bywhole-brain radiotherapy (WBRT) for brain metastasis (BM) with (n = 21) or without (n = 21) meningeal dissemination.The median prescribed dose of GK was 14 Gy at the periphery. The median WBRT dose to isocenter was 30 Gy in 10 fractions. The median number of target BM was 15.
33 did not develop further recurrence until death or last follow-up, while 9 developed recurrence. With a follow-up period up to 24 months, the overall survival rate was 34% at 12 months and median survival time was 8 months. The cumulative incidence of intracranial recurrence was 23% at 12 months. Treatment with low-dose GK followed by WBRT for advanced-stage BM appeared to contribute to local control. Adverse events were mostly acceptable.

Free Research Field

放射線腫瘍学