Establishment of a longitudinal quantitative assessment method for carotid artery plaques using three-dimensional high-contrast MRI

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19813
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: Oura Mao 岩手医科大学, 医学部, 助教 (60713899)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 頸動脈プラーク / 頸動脈MRI / 頸動脈エコー

Outline of Final Research Achievements

In this study, eligible patients with hyperuricemia and a carotid plaque, confirmed by an ultrasound examination, were enrolled and divided into two groups: a febuxostat administration group and a non-administration group. Changes in properties of the internal plaque over time were monitored in order to investigate the effect of febuxostat on atherosclerotic lesions. Monitoring was carried out using 3D carotid artery ultrasonography and carotid artery MR plaque imaging with a 1.5 T MRI scanner via a 3D high contrast imaging method (3D-FSE). Enrollment of eligible patients did not progress well and many patients dropped out after enrollment. As a result, we were unable to collect sufficient data for analysis.

Free Research Field

神経内科