Development of novel radiosensitizers for improving radiation therapy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19814
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: SAITO Yohei 東北医科薬科大学, 薬学部, 助教 (10613698)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 放射線耐性 / 細胞死 / トランスグルタミナーゼ２

Outline of Final Research Achievements

To development of radiosensitizers for the purpose of improving the effectiveness of combination therapy with radiation and expanding of indications, we studied the effect of transglutaminase 2, which contributed to cancer cell survival and metastasis, on the radioresistance and its mechanism. Although TG2 overexpressing enhanced the cell viability after ionizing radiation, TGase activity or GTPase activity of TG2 is not necessary for the action. However, TG2-C277S expressing increased cell death after ionizing radiation on clinically-radioresistant cell. Membrane-anchored TG2 expressing cells showed the strong resistance to cell death under serum starvation condition, but did not suppress the anticancer drugs- or ionizing radiation-induced cell death.

Free Research Field

細胞生物学