Development of imaging probes for systemic amyloidosis diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19827
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Nagasaki University (2016); Kobe Pharmaceutical University (2015)
• Principal Investigator: HAGIMORI Masayori 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (40446125)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 全身性アミロイドーシス / 早期診断 / 核医学イメージングプローブ / 蛍光イメージングプローブ

Outline of Final Research Achievements

For diagnosis and monitoring therapeutic efficacy of systemic amyloidosis diseases, we planned to develop a nuclear imaging probe with similar binding affinities to a variety of amyloid fibrils and fluorescent probes with a selective binding affinity to a specific amyloid fibril. Radioiodine labelled compound [125I]1 based on the structure of thioflavine T showed similar binding affinities to SAA fibril and Aβ fibril. In AA amyloid model mice, considerable accumulation of radioactivity was observed in predilection sites of AA amyloid such as the spleen, kidney, and liver. In addition, we synthesized fluorescent probes with a selective binding affinity to a specific amyloid fibril by investigating substituent groups.

Free Research Field

薬学