An optimized measurement of effort breath by functional MRI

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19828
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: Oda Hanako 久留米大学, 医学部, 助教 (40569422)
• Research Collaborator: KAWAYAMA Tomotaka 久留米大学, 医学部, 教授 (80289389) ; KINOSHITA Takashi 久留米大学, 医学部, 助教 (90454917) ; TANIWAKI Takayuki 久留米大学, 医学部, 教授 (80284496) ; KAKUMA Tatsuyuki 久留米大学, 付置研究所, 教授 (50341540)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 核磁気共鳴画像（MRI）

Outline of Final Research Achievements

Our objective was to determine the resting state networks during dyspnea. Differences between normal and effort breathing(EB) were investigated using FMRIB Software Library tools. For intra-network connectivity changes, EB caused significant connectivity increase within the cerebellum and the anterior insular-anterior cingulate cortex network. For inter-network connectivity changes, we found higher connectivity between the posterior parietal cortex and the spatial attention network, between the posterior parietal cortex and the lateral prefrontal cortex during EB. In contrast, EB showed lower connectivity between the anterior insular-anterior cingulated cortex network and the sensori-motor network, between the ventro-medial prefrontal cortex and the posterior parietal cortex. These results suggest the increased connectivity within the salience network and central executive network, while decreased connectivity within the default mode network and inter-network connectivity in EB.

Free Research Field

医歯薬学