Quantitative evaluation for interfractional organ motion in radiation therapy.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K19837
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: Kobayashi Kazuma 国立研究開発法人国立がん研究センター, 中央病院, レジデント (00747610)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 放射線治療 / 非剛体レジストレーション / 有害事象評価 / 時空間的線量合算

Outline of Final Research Achievements

One of the limitations in the current practice of radiotherapy is that the cumulative, sub-volume doses of organs at risk over the course of fractionated treatment are difficult to be assessed. To quantify the interfactional topographic and dosimetric changes, we adopted a surface-based non-rigid registration by a Gaussian mixture model to document the changing patient anatomy. The proposed method enabled spatiotemporal summation of irradiated radiation doses and predicted the location-by-location difference in the severity of late radiation injury. We will develop the method to establish three-dimensional statistical analysis based on the anatomical standardization for predicting clinical effects in radiation therapy.

Free Research Field

放射線治療