2018 Fiscal Year Final Research Report
Effect of CSF-1 receptor inhibitor for the acute rejection after intestinal transplantation
| Project/Area Number |
15K19842
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 小腸移植 / 急性拒絶反応 / 自然免疫 / 臓器保存 |
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| Outline of Final Research Achievements |
I analyzed whether the CSF-1 receptor inhibitor reduce the acute rejection after intestinal transplantation. As result, CSF-1 receptor inhibitor reduced the finding of the acute rejection after intestinal transplantation by rat.
Furthermore, I performed the research of the solution of the intestinal preservation. After 24 hours, the intestine preserved by the solution of intracellular / extracellular composition were pathologically better than that by saline.
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| Free Research Field |
小児外科、小腸移植
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| Academic Significance and Societal Importance of the Research Achievements |
CSF-1受容体阻害剤が、小腸移植後急性拒絶を軽減したことは、このメカニズムにおけるマクロファージの役割が大きいことを示し、また新たな免疫浴療法のターゲットとなり得ることを示した。この成果により、小腸移植後急性拒絶がさらに制御され、小腸移植成績が向上することは、現在治療に難渋している腸管不全患者にとっても朗報となり得ると考えている。
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