2016 Fiscal Year Final Research Report
Discovery of long non-coding RNA biomarkers for predicting the prognosis of HCC
| Project/Area Number |
15K19848
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | lncRNA / 肝細胞癌 / リスク因子 / 背景肝 |
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| Outline of Final Research Achievements |
Long non-coding RNAs (lncRNAs) were shown to be the crucial regulators of the development of many diseases, including malignant neoplasms. In this study, we evaluated the effects of lncRNA expression levels in hepatocellular carcinoma (HCC) on postsurgical HCC prognosis. The candidate lncRNAs were identified by using the microarray assay. The expression levels of HULC and MALAT1 were shown to be significantly higher in the normal background tissue of HCC than those in the normal liver tissue of metastatic liver tumor without hepatitis. The increase in the expression levels of HULC and MALAT1 in HCC was significantly correlated with better overall survival of the patients. Expression levels of HULC and MALAT1 in HCC were shown to be significantly associated with the prognosis of curably resected HCC. The expression of these lncRNAs in HCC may correlate with the HCC malignancy. HULC and MALAT1 may represent potential prognostic biomarkers of the surgically resected HCC.
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| Free Research Field |
消化器外科学
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